KMID : 1038920220210040156
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Annals of Optometry and Contact Lens 2022 Volume.21 No. 4 p.156 ~ p.162
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Association of Optic Disc Hyperfluorescence with Subclinical Macular and Optic Disc Edema in Uveitis Patients
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Bae Kun-Ho
Yoon Chang-Ki Lee Eun-Kyoung Lee Jae-Hyup Yu Hyeong-Gon
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Abstract
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Purpose: To investigate the frequency of optic disc hyperfluorescence (ODH) and their association with macular and optic nerve head thickness in patients with active uveitis.
Methods: This retrospective cross-sectional study included 37 eyes of 30 patients with active noninfectious uveitis who underwent spectral domain-optical coherence tomography (OCT) and fluorescein angiography. OCT parameters were compared between baseline and post-treatment according to the ODH.
Results: ODH was observed clearly in 22 eyes (64.7%) and equivocally in five eyes (14.7%) at baseline. In subgroup analysis without clinically significant optic disc edema, central subfield thickness, peripapillary retinal nerve fiber layer thickness, disc rim area, and disc area were 262.2 ¥ìm, 110.9 ¥ìm, 1.49 mm2, and 2.02 mm2 at baseline and significantly decreased after treatment (249.5 ¥ìm, 102.1 ¥ìm, 1.34 mm2, and 1.95 mm2, respectively) in eyes with ODH (p = 0.044, p < 0.001, p = 0.001, p = 0.024, respectively).
However, there was no significant changes in the eyes without ODH (all p > 0.05).
Conclusions: There was a difference in the thickness reduction of the macula and optic nerve head according to the ODH.
Baseline ODH should be regarded as a sign of ocular inflammation and carefully monitored.
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KEYWORD
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Fluorescein angiography, Macular edema, Optical coherence tomography, Optic disc edema, Uveitis
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